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  Home > JCE Print > Journal of Chemical Education > Issues > 2000  > November  >
Chemistry for Everyone
Products of Chemistry
Developing New Antibiotics with Combinatorial Biosynthesis
Nicola L. Pohl
Department of Chemistry and the Plant Sciences Institute, Iowa State University, Ames, IA 50011-3111
Cover
November 2000
Vol. 77 No. 11
p. 1421
Abstract
Polyketide synthases (PKSs), a class of enzymes found in soil bacteria that produce antibiotics such as erythromycin, string together acetate units using basic organic reactions. The manipulation of the sequence of these reactions at the genetic level has resulted in an alteration of the corresponding chemical structure of the antibiotic produced by the bacteria. This process, called combinatorial biosynthesis, allows the generation of many presently unknown complex structures that can be tested for antibacterial activity, thereby contributing to the race against antibiotic-resistant infectious bacteria.
More Information
*  Citation
 Pohl, Nicola L. J. Chem. Educ. 2000 77 1421.
*  Keywords
 Biotechnology; Drugs / Pharmaceuticals; Enzymes; Natural Products; Organic Chemistry
*  History
 Created:
Last Updated:		 October 6, 2000
April 15, 2005
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