Determination of the Dissociation Constant for Monoprotic Acid by Simple pH Measurements
R. García-Doménech, J. V. de Julián-Ortiz, G. M. Antón-Fos, and J. Galvez Alvarez
Department of Physical Chemistry, Faculty of Pharmacy, University of Valencia, Spain
The dissociation constant for a weak monoprotic acid may be calculated in aqueous alkaline solution by straightforward pH measurements, before and after the addition of the acid, and with the advantage of not having to standardize the solutions. The proposed experimental procedure is particularly interesting in the case of organic acids that are slightly soluble in water.
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