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1999
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November
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In the Laboratory
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A Novel Target Synthesis Laboratory for Students
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C. Mark Smales and David R. K. Harding
Department of Chemistry, Massey University, Palmerston North, New Zealand
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November 1999
Vol. 76 No. 11
p. 1558
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| Abstract |
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A third-year specialist course in drug design and delivery focused on a single laboratory goal for all students. A tetrapeptide, destined as the signal component of a drug delivery system, was chosen for this target synthesis. The practical, real-life aspect of the course, and the target synthesis in particular, was a major component of the appeal to the students. Students were given a synthetic scheme based on standard peptide synthesis protocols, and several lectures provided background for the general approach. They were then encouraged to design each step of the synthesis themselves, with reference to the literature and course work. As long as due diligence was shown in attempts to achieve success at each step, no student was penalized for losses, low yields, or other lack of progress. Reports on all procedures used were prepared in a journal format chosen by the student and were collected at the end of the course. The target-synthesis approach was appreciated by the students and enjoyed by the staff. We believe the students left the course with a greater appreciation for laboratory research. It takes more work to set up and run this type of course than the traditional follow-the-recipe course, but in our experience it was worth the extra effort.
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| More Information |
 Citation |
Smales, C. Mark; Harding, David R. K. J. Chem. Educ. 1999 76 1558.
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Keywords |
Laboratory Instruction; Drugs / Pharmaceuticals; Synthesis; Proteins / Peptides; Problem-Based Learning
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History |
Created:
Last Updated: |
October 12, 1999
June 23, 2005
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| Home > JCE Print > Journal of Chemical Education > Issues >
1999
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November
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1558
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