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  Home > JCE Print > Journal of Chemical Education > Issues > 2004  > July  >
In the Classroom
JCE DigiDemos: Tested Demonstrations
Demonstration of Enantiomer Specificity of Proteins and Drugs
Gretchen L. Anderson
Department of Chemistry, Indiana University–South Bend, South Bend, IN 46634-7111

checked by Shallee T. Page
Department of Chemistry and Biochemistry, University of Maine–Machias, Machias, ME 04654

Cover
July 2004
Vol. 81 No. 7
p. 971
Abstract
In addition to the traditional use of molecular models of tetrahedral asymmetric centers, the concept of chirality and its importance to protein–drug interactions is demonstrated in a guided classroom activity. A watchglass with three different colored Post-it Notes is set on a desktop or table surface to simulate a molecular binding site of a protein. As students build models of symmetric and asymmetric centers, the models are tested for binding to the watchglass "binding site". By relating the chiral or achiral models to various common or familiar drugs, students can easily understand the importance of chirality in protein–drug interactions. This approach can be easily adapted to the knowledge base of the student and can include concepts of prochirality, nomenclature, properties, and chemical separation schemes of enantiomers.

See the Discussion on this Tested Demonstation.

See Featured Molecules.

More Information
*  Citation
 Anderson, Gretchen L. J. Chem. Educ. 2004 81 971.
*  Keywords
 Biochemistry; Chirality / Optical Isomers; Demonstrations; Drugs / Pharmaceuticals; Enzymes; General Chemistry; Introductory / High School Chemistry; Organic Chemistry
*  History
 Created:
Last Updated:		 May 27, 2004
January 21, 2005
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