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  Home > JCE Print > Journal of Chemical Education > Issues > 2004  > June  >
In the Laboratory
Green Chemistry
One-Pot Synthesis of 7-Hydroxy-3-carboxycoumarin in Water
Francesco Fringuelli, Oriana Piermatti, and Ferdinando Pizzo
Dipartimento di Chimica, Università di Perugia, 8 - 06123 Perugia, Italy
Cover
June 2004
Vol. 81 No. 6
p. 874
Abstract
7-Hydroxy-3-carboxycoumarin is prepared by a one-pot consecutive process, carried out in water, starting from 2,4-dihydroxybenzaldehyde and malononitrile. The procedure highlights the advantages of using an aqueous medium, particularly the possibility of controlling the pH and isolating the reaction product without using any organic solvent.

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Supplement
Instructions for the students, notes for the instructor, and interpretation of the TLC plates and IR, 1H and 13C NMR spectra are available.
*  Contents JCE2004p0874W.doc (Microsoft Word)
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More Information
*  Citation
 Fringuelli, Francesco; Piermatti, Oriana; Pizzo, Ferdinando. J. Chem. Educ. 2004 81 874.
*  Keywords
 Aqueous Solution Chemistry; Green Chemistry; Heterocycles; Laboratory Instruction; Organic Chemistry; Organic Synthesis
*  History
 Created:
Last Updated:		 May 2, 2004
January 21, 2005
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