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  Home > JCE Print > Journal of Chemical Education > Issues > 2007  > June  >
In the Classroom
Receptor Surface Models in the Classroom: Introducing Molecular Modeling to Students in a 3-D World
Werner J. Geldenhuys, Michael Hayes, Cornelis J. Van der Schyf, and David D. Allen
Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX 79106

Sarel F. Malan
Pharmaceutical Chemistry, School of Pharmacy, North-West University, Potchefstroom, 2520, South Africa

Cover
June 2007
Vol. 84 No. 6
p. 979
Abstract
In this study we propose a novel method of teaching interactions of drugs with a receptor, enzyme, or any other macromolecule or protein using plastic molecular models and aluminum foil. In the university setting, computer modeling software or textbooks are often used in this regard, but many students have difficulty interpreting the three dimensionality of drug–macromolecule interaction from these sources. By introducing a receptor surface model (RSM) for a small congeneric series of blood–brain barrier choline transporter (BBB-ChT) substrates as an example, students are able to investigate concepts such as steric interaction and hydrogen-bond interactions that are important concepts in medicinal chemistry and drug design.
More Information
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Citation
Geldenhuys, Werner J.; Hayes, Michael; Van der Schyf, Cornelis J.; Allen, David D.; Malan, Sarel F. J. Chem. Educ. 2007, 84, 979.
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Keywords
Biochemistry; Bioorganic Chemistry; Computer-Based Learning; Drugs / Pharmaceuticals; First-Year Undergraduate / General; Graduate Education / Research; Hands-On Learning / Manipulatives; Laboratory Computing / Interfacing; Medicinal Chemistry; Molecular Modeling; Second-Year Undergraduate
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History
Created:
Last Updated:
4/24/2007
5/2/2007
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