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  Home > JCE Print > Journal of Chemical Education > Issues > 2008  > May  >
In the Classroom
Introduction to Protein Structure through Genetic Diseases
Tanya L. Schneider and Brian R. Linton
Department of Chemistry, Bowdoin College, Brunswick, ME 04011
Cover
May 2008
Vol. 85 No. 5
p. 662
Abstract
An illuminating way to learn about protein function is to explore high-resolution protein structures. Analysis of the proteins involved in genetic diseases has been used to introduce students to protein structure and the role that individual mutations can play in the onset of disease. Known mutations can be correlated to changes in protein activity, structure, or processing. Students gain the skills to manipulate high-resolution protein structures and an understanding of how structural changes can lead to disease.
Supplement
A brief description of each disease is given to highlight the relevant aspects of protein structure.
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Citation
Schneider, Tanya L.; Linton, Brian R. J. Chem. Educ. 2008, 85, 662.
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Keywords
Biochemistry; Computer-Based Learning; Enzymes; Inquiry-Based / Discovery Learning; Medicinal Chemistry; Molecular Properties / Structure; Proteins / Peptides; Student-Centered Learning; Upper-Division Undergraduate; X-ray Crystallography
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History
Created:
Last Updated:
3/25/2008
3/28/2008
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